The evolution and development of magnum handgun cartridges, taken as a whole, is quite interesting. This study clearly reflects the development of the American handgunner and innovations within our firearms industry. It's also a good reminder for why we should never say "never."
... the .44 Magnum was just the beginning in the world of handgun power. It's still a wonderful cartridge, and it taught us all about grip design and recoil management. Those lessons learned with the .44 Magnum have paved the way for the current crop of massive, magnum handguns. And while I really can't imagine wanting to shoot a revolver that is more powerful than the big .460 and .500, I'm not about to say that this is where it all ends. Somebody would undoubtedly come along and make a liar out of me.